Malaria is one of the most serious tropical diseases and can be fatal if not diagnosed and treated at an early stage.
Benefits of Atovaquone & Proguanil Hydrochloride in Malaria prophylaxis
95 – 100% protection against Plasmodium falciparum malaria.1
Atovaquone & Proguanil Hydrochloride showed the best safety profile when compared to other Malaria Prophylaxis. Adverse events comparable to placebo.1
Convenient once daily dosage.2 Shortest pretravel and post travel regime.1,2
References: 1. McKeage K, Scott LJ. Atovaquone/Proguanil: A review of its use for the prophylaxis of Plasmodium falciparum malaria. Drugs 2003; 63(6):597-623. 2. MOZITEC Package Insert (November 2014). 3. Medicines Control Council – communication to industry. Scheduling Matters: Rescheduling of atovaquone and proguanil. December 2017. 4. South African Guidelines for the Prevention of malaria 2017. Available at: http://www.nicd.ac.za/wp-content/uploads/2019/09/Guilines-South-African- Guidlinesfor-the-Prevention-of-Malaria-2017-final.pdf. Accessed 11 November 2018.
Myths and misconceptions regarding malaria abound – some dangerous and others causing unnecessary concern.
One of the most dangerous myths is that malaria chemoprophylaxis masks the symptoms of malaria making it more difficult to diagnose the disease.
Most antimalarial medicines do not prevent infection but have an effect on the parasites after they have entered the body. The medicine prevents the parasites from multiplying, invading other red blood cells, and clogging arteries to the brain and other vital organs, and as a result, no symptoms of malaria are manifested.
If chemoprophylaxis is inadequate (due to drug resistance or poor compliance), malaria parasites will be able to multiply and cause clinical malaria.
If prophylaxis is partially effective, it may take longer for the disease to manifest and for the symptoms to present, and the symptoms may initially be milder because the infection itself is milder. The risk of severe malaria and malaria-related death is lower at this stage. However, once the infection increases in intensity and results in clinical disease, the symptoms present with greater intensity. The time that it takes for the disease to progress from uncomplicated malaria to severe malaria may therefore be longer if the individual has taken malaria chemoprophylaxis.