Erectile dysfunction (ED) is a common complaint in general medical practice.¹

Prevalence of partial or complete ED is 50% in men aged 40 to 70, and prevalence increases with aging.²

ED is generally related to vascular, neurologic, psychologic, and hormonal disorders.²

Tadalafil is a safe, well tolerated, and efficacious treatment for most severities and aetiologies of ED³.

• Potent, reversible, and selective inhibitor of PDE5^4-6.
  • In response to sexual stimulation, ED is improved by increasing blood flow to the
    penis.⁵
• Proven efficacy in numerous ED clinical trials³
• Most unique characteristic is the long half-life of 17.5 hours.^3,5,6 – Resulting in a longer therapeutic window with on-demand dosing and effective steady-state plasma concentrations with once-daily dosing.³
• Offers a convenient on-demand or once-daily dosing regimen.^5,6
• In a direct comparison with sildenafil:⁷
  • Tadalafil had significantly better psychological outcomes compared to sildenafil.
  • Patients preferred tadalafil over sildenafil.
  • Tadalafil may be a better choice for ED treatment.

Indications^5,6

• Tadalafil is indicated for the treatment of erectile dysfunction in
  adult males.
• Sexual stimulation is required in order for Tadalafil to be effective.

References: 1. Yovwin DG, Imarhiagbe FA, Obazee EM, Oguike TC. Erectile dysfunction in a sub-saharan African population: Profile and correlates in a tertiary care hospital. Sahel Medical Journal 2015; 18(3):116-120. 2. Hirsch IH. Erectile Dysfunction – MSD Manual Professional Version. Available at: https://www.msdmanuals.com/professional/genitourinary-disorders/male-sexual-dysfunction/erectile-dysfunction?query=Erectile%20Dysfunction%20(ED)#. Accessed 25 November 2021. 3. Coward RM, Carson CC. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management 2008; 4(6):1315-1329. 4. De Tejada IS, Anglin G, Knight JR, Emmick JT. Effects of Tadalafil on Erectile Dysfunction in Men With Diabetes. Diabetes Care 2002; 25:2159-2164. 5. TALVIOR 5 Professional Information (April 2020). 6. TALVIOR 20 Professional Information (April 2020). 7. Gong B, Ma M, Xie W, et al. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. Int Urol Nephrol 2017; 49:1731-1740. 8. Data on file.